Breadcrumb Home Applications Gallery Gallery Applications Videos Gallery Library of Recent Studies Cancer Biology M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance. Bailleul et al. 2023. Neuro-Oncology. Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Han et al. 2023. Nature. Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy. Wang et al. 2021. Cancer Cell. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Momcilovic et al. 2019. Nature. Immunotherapy Low-dose exposure to PBDE disrupts genomic integrity and innate immunity in mammary tissue. Lamkin et al. 2022. Frontiers in Genetics. Immuno-PET in Inflammatory Bowel Disease: Imaging CD4-Positive T Cells in a Murine Model of Colitis. Freise et al. 2018. Journal of Nuclear Medicine ImmunoPET of Malignant and Normal B Cells with 89Zr- and 124I-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo. Zettlitz et al. 2017. Clinical Cancer Research Detection of immune responses after immunotherapy in glioblastoma using PET and MRI. Antonios et al. 2017. Proceedings of the National Academy of Sciences of the United States of America. Neuroscience Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities. Khoja et al. 2022. Molecular Therapy. Methods and Clinical Development. Regional distribution of SGLT activity in rat brain in vivo. Yu et al. 2013. American Journal of Physiology. [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment. Teng et al. 2011. Neurobiology of Diseases. Cardiology Changes in microarchitecture of atherosclerotic calcification assessed by 18F-NaF PET and CT after a progressive exercise regimen in hyperlipidemic mice. Hsu et al. 2021. Journal of Nuclear Cardiology. Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice. Xian et al. 2021. Arteriosclerosis, Thrombosis, and Vascular Biology. Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Hsu et al. 2018. American Journal of Physiology. Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Hsu et al. 2018. American Journey of Physiology. Drug Development An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1-HK2+ Multiple Myeloma. Xu et al. 2019. Cancer Research. A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Xu et al. 2018. Cancer and Metabolism. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. Murphy et al. 2013. Journal of Medicinal Chemistry. On-demand drug release system for in vivo cancer treatment through self-assembled magnetic nanoparticles. Lee et al. 2013. Angewandte Chemie. Accurate Measure by High-Resolution CT Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice. Vuong et al. 2021. Behavioral Brain Research. Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities. Khoja et al. 2022 Molecular Therapy. Imaging Technology Development High-throughput radio-TLC analysis. Wang et al. 2021. Nuclear Medicine and Biology. Performance evaluation of HiPET, a high sensitivity and high resolution preclinical PET tomograph. Gu et al. 2020. Physics in Medicine and Biology. Prediction of major torso organs in low-contrast micro-CT images of mice using a two-stage deeply supervised fully convolutional network. Wang et al. 2019. Physics in Medicine and Biology. Performance evaluation of G8, a high sensitivity benchtop preclinical PET/CT tomograph. Radiochemistry Technology Development High-pressure, compact, modular radiosynthesizer for production of positron emitting biomarkers Simplified programming and control of automated radiosynthesizers through unit operations High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress A simple and efficient automated microvolume radiosynthesis Probe and Assay Development Comparison of the Efficacy and Sensitivity of Alternative PET Reporter Gene/PET Reporter Probe Systems That Minimize Biological Variables A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging INDs for PET molecular imaging probes-approach by an academic institution. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Tracer Kinetic Modeling Improved modeling of in vivo kinetics of slowly diffusing radiotracers for tumor imaging. Improved derivation of input function in dynamic mouse [18F]FDG PET using bladder radioactivity kinetics. Influence of dietary state and insulin on myocardial, skeletal muscle and brain [F]-fluorodeoxyglucose kinetics in mice. Effects of administration route, dietary condition, and blood glucose level on kinetics and uptake of 18F-FDG in mice.