Gallery

Library of Recent Studies

Cancer Biology

PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity

PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity. Varuzhanyan et al. 2024. Proc Natl Acad Sci U S A.

89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors

89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors. Chan et al. 2024. Mol Cancer Ther.

18F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma

18F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma. Narayanam et al. 2023. Chem Sci.

M2 isoform of pyruvate kinase rewires glucose

M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance. Bailleul et al. 2023. Neuro Oncol. 

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Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Han et al. 2023. Nature.

Mice Imaging Example

Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy. Wang et al. 2021. Cancer Cell.

In vivo imaging example

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Momcilovic et al. 2019. Nature.

Immunotherapy

Lamkin (1).

Low-dose exposure to PBDE disrupts genomic integrity and innate immunity in mammary tissue. Lamkin et al. 2022. Front Genet.

Immuno-PET in Inflammatory Bowel Disease

Immuno-PET in Inflammatory Bowel Disease: Imaging CD4-Positive T Cells in a Murine Model of Colitis. Freise et al. 2018. J Nucl Med.

ImmunoPET of Malignant and Normal B Cells

ImmunoPET of Malignant and Normal B Cells with 89Zr- and 124I-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo. Zettlitz et al. 2017. Clin Cancer Res.

Detection of immune responses after immunotherapy in glioblastoma

Detection of immune responses after immunotherapy in glioblastoma using PET and MRI. Antonios et al. 2017. Proc Natl Acad Sci U S A.

Neuroscience

[18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation

[18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation. Day et al. 2025. Sci Rep.

Gene therapy for guanidinoacetate methyltransferase deficiency

Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities. Khoja et al. 2022. Mol Ther Methods Clin Dev.

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Regional distribution of SGLT activity in rat brain in vivo. Yu et al. 2013. Am J Physiol Cell Physiol.

[F-18]FDDNP microPET imaging correlates with brain Aβ burden

[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment. Teng et al. 2011. Neurobiol Dis.

Cardiology

Preclinical evaluation of high-resolution CT, 18F-FDG, and 18F-NaF PET imaging for longitudinal monitoring of atherosclerosis

Preclinical evaluation of high-resolution CT, 18F-FDG, and 18F-NaF PET imaging for longitudinal monitoring of atherosclerosis. Tamboline et al. 2025. Eur J Nucl Med Mol Imaging.

A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction

A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction. Li et al. 2024. Cell Rep Med.

Invasive electrochemical impedance spectroscopy with phase delay for experimental atherosclerosis phenotyping

Invasive electrochemical impedance spectroscopy with phase delay for experimental atherosclerosis phenotyping. Chen et al. 2024. FASEB J.

Changes in microarchitecture of atherosclerotic calcification

Changes in microarchitecture of atherosclerotic calcification assessed by 18F-NaF PET and CT after a progressive exercise regimen in hyperlipidemic mice. Hsu et al. 2021. J Nucl Cardiol.

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Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice. Xian et al. 2021. Arterioscler Thromb Vasc Biol.
 

Statin Effects

Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice. Xian et al. 2021. Arterioscler Thromb Vasc Biol.

Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice

Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Hsu et al. 2018. Am J Physiol Heart Circ Physiol.

Metabolism

PPARγ-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity

PPARγ-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity. Siqueira et al. 2024. Cell Rep.

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling. Tol et al. 2025. Nat Metab.


 

Drug Development

Recent developments in translational imaging of in vivo gene therapy outcomes

Recent developments in translational imaging of in vivo gene therapy outcomes. Day et al. 2025. Mol Ther.

A Glucose-Responsive Glucagon-Micelle for the Prevention of Hypoglycemia

A Glucose-Responsive Glucagon-Micelle for the Prevention of Hypoglycemia. Vinciguerra et al. 2024. ACS Cent Sci.

A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction

 

A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction. Li et al. 2024. Cell Rep Med.

An HK2 Antisense Oligonucleotide Induces Synthetic Lethality

An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1-HK2+ Multiple Myeloma. Xu et al. 2019. Cancer Res.

A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers

A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Xu et al. 2018. Cancer Metab.

Development of new deoxycytidine kinase inhibitors

Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. Murphy et al. 2013. J Med Chem.

On-demand drug release system for in vivo cancer treatment

On-demand drug release system for in vivo cancer treatment through self-assembled magnetic nanoparticles. Lee et al. 2013. Angew Chem Int Ed Engl.

Accurate Measurements by High-Resolution CT and MRI

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Supramolecular hydrogel actuators with reprogrammable magnetic orientation by locally mediated viscoelasticity and pinning force. Zhang et al. 2025. Sci Adv.

Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities

Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities. Khoja et al. 2022. Mol Ther Methods Clin Dev.

Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice

Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice. Vuong et al. 2021. Behav Brain Res.

Imaging Technology Development

Real-Time in Vivo Bacterial Imaging by Computed Tomography and Fluorescence Using Phage-Gold Nanorod Bioconjugates as Contrast Agents

Real-Time in Vivo Bacterial Imaging by Computed Tomography and Fluorescence Using Phage-Gold Nanorod Bioconjugates as Contrast Agents. Peng et al. 2025. ACS Biomater Sci Eng.

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph. Taschereau et al. 2025. J Vis Exp.

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images. Day et al. 2024. J Vis Exp.

High-throughput radio-TLC analysis

High-throughput radio-TLC analysis. Wang et al. 2021. Nucl Med Biol.

PMID31935693a

Performance evaluation of HiPET, a high sensitivity and high resolution preclinical PET tomograph. Gu et al. 2020. Phys Med Biol.

Prediction of major torso organs in low-contrast micro-CT images of mice using a two-stage deeply supervised fully convolutional network

Prediction of major torso organs in low-contrast micro-CT images of mice using a two-stage deeply supervised fully convolutional network. Wang et al. 2019. Phys Med Biol.

PMC6354226

Performance Evaluation of G8, a High-Sensitivity Benchtop Preclinical PET/CT Tomograph. Gu et al. 2019. J Nucl Med.

3D Printing for Understanding Anatomy

Understanding Cardiac Anatomy and Imaging to Improve Safety of Procedures: The Subclavian Artery and Vein

Understanding Cardiac Anatomy and Imaging to Improve Safety of Procedures: The Subclavian Artery and Vein. Sato et al. 2025. JACC Case Rep.

Understanding Cardiac Anatomy and Imaging to Improve Safety of Procedures: The Femoral Artery and Vein: Part 2

Understanding Cardiac Anatomy and Imaging to Improve Safety of Procedures: The Femoral Artery and Vein: Part 2. Sato et al. 2024. JACC Case Rep.

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Pipeline for Multi-Scale Three-Dimensional Anatomic Study of the Human Heart. Hanna et al. 2024. J Vis Exp.

Radiochemistry Technology Development

Rapid Concentration of Ga-68 and Proof-of-Concept Microscale Labeling of [68Ga]Ga-PSMA-11 in a Droplet Reactor

Rapid Concentration of Ga-68 and Proof-of-Concept Microscale Labeling of [68Ga]Ga-PSMA-11 in a Droplet Reactor. Lu et al. 2024. Molecules.

Scalable droplet-based radiosynthesis of [18F]fluorobenzyltriphenylphosphonium cation ([18F]FBnTP) via a "numbering up" approach

Scalable droplet-based radiosynthesis of [18F]fluorobenzyltriphenylphosphonium cation ([18F]FBnTP) via a "numbering up" approach. Lu et al. 2024. Lab Chip.

Proof-of-concept optimization of a copper-mediated 18F-radiosynthesis of a novel MAGL PET tracer on a high-throughput microdroplet platform and its macroscale translation

Proof-of-concept optimization of a copper-mediated 18F-radiosynthesis of a novel MAGL PET tracer on a high-throughput microdroplet platform and its macroscale translation. Lu et al. 2023. Lab Chip.
 

Accelerating radiochemistry development: Automated robotic platform for performing up to 64 droplet radiochemical reactions in a morning

Accelerating radiochemistry development: Automated robotic platform for performing up to 64 droplet radiochemical reactions in a morning. Jones et al. 2023. Chem Eng J.

Detrimental impact of aqueous mobile phases on 18F-labelled radiopharmaceutical analysis via radio-TLC

Detrimental impact of aqueous mobile phases on 18F-labelled radiopharmaceutical analysis via radio-TLC. Laferriere-Holloway et al. 2023. Anal Methods.

High-pressure, compact, modular radiosynthesizer for production of positron emitting biomarkers

High-pressure, compact, modular radiosynthesizer for production of positron emitting biomarkers. Amaraesekera et al. 2013. Appl Radiat Isot.

PMC3717018

Simplified programming and control of automated radiosynthesizers through unit operations. Clagget et al. 2013. EJNMMI Res.

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High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress. Wang et al. 2020. Mol Imaging.

PMC7718361

A simple and efficient automated microvolume radiosynthesis of [18F]Florbetaben. Lisova et al. 2020. EJNMMI Radiopharm Chem.

Probe and Assay Development

Comparison of the Efficacy and Sensitivity of Alternative PET Reporter Gene/PET Reporter Probe Systems That Minimize Biological Variables

Comparison of the Efficacy and Sensitivity of Alternative PET Reporter Gene/PET Reporter Probe Systems That Minimize Biological Variables. Xu et al. 2020. Methods Mol Biol. 

PMC4829938

A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging. Hoover et al. 2016. Organometallics.

INDs for PET molecular imaging probes-approach by an academic institution

INDs for PET molecular imaging probes-approach by an academic institution. Mosessian et al. 2014. Mol Imaging Bio.

Clark

Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Clark et al. 2014. Proc Natl Acad Sci U S A.

Tracer Kinetic Modeling

Improved modeling of in vivo kinetics of slowly diffusing radiotracers for tumor imaging.

Improved modeling of in vivo kinetics of slowly diffusing radiotracers for tumor imaging. Wilks et al. 2014. J Nucl. Med.
 

Improved derivation of input function in dynamic mouse [18F]FDG PET using bladder radioactivity kinetics

Improved derivation of input function in dynamic mouse [18F]FDG PET using bladder radioactivity kinetics. Wong et al. 2013. Mol Imaging Biol.

Kreissl

Influence of dietary state and insulin on  myocardial, skeletal muscle and brain [F]-fluorodeoxyglucose kinetics in mice.

Effects of administration route, dietary condition, and blood glucose level on kinetics and uptake of 18F-FDG in mice

Effects of administration route, dietary condition, and blood glucose level on kinetics and uptake of 18F-FDG in mice. Wong et al. 2011. J Nucl Med.