Breadcrumb Home Applications Applications Library of Recent StudiesCancer Biology Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. PKM2 rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance. Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Immunotherapy Low-dose exposure to PBDE disrupts genomic integrity and innate immunity in mammary tissue. Immuno-PET in Inflammatory Bowel Disease: Imaging CD4-Positive T Cells in a Murine Model of Colitis. ImmunoPET of Malignant and Normal B Cells with 89Zr- and 124I-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo. Detection of immune responses after immunotherapy in glioblastoma using PET and MRI. Neuroscience Regional distribution of SGLT activity in rat brain in vivo. [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade. Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities. [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade. Cardiology Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice Changes in microarchitecture of atherosclerotic calcification assessed by 18F-NaF PET and CT after a progressive exercise regimen in hyperlipidemic mice Statin Effects on Vascular Calcification Effects of bone anabolic therapy on progression of calcific aortic vasculopathy in Apoe-/- mice Drug Development An HK2 antisense oligonucleotide induces synthetic lethality in HK1-HK2+ multiple myeloma A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography On-demand drug release system for in vivo cancer treatment through self-assembled magnetic nanoparticles. Accurate Measure by High-Resolution CT Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities Imaging Technology Development High-throughput radio-TLC analysis. Performance evaluation of HiPET, a high sensitivity and high resolution preclinical PET tomograph. Prediction of major torso organs in low-contrast micro-CT images of mice using a two-stage deeply supervised fully convolutional network. Performance evaluation of G8, a high sensitivity benchtop preclinical PET/CT tomograph. Radiochemistry Technology Development High-pressure, compact, modular radiosynthesizer for production of positron emitting biomarkers Simplified programming and control of automated radiosynthesizers through unit operations High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress A simple and efficient automated microvolume radiosynthesis Probe and Assay Development Comparison of the Efficacy and Sensitivity of Alternative PET Reporter Gene/PET Reporter Probe Systems That Minimize Biological Variables A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging INDs for PET molecular imaging probes-approach by an academic institution. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Tracer Kinetic Modeling Improved modeling of in vivo kinetics of slowly diffusing radiotracers for tumor imaging. Improved derivation of input function in dynamic mouse [18F]FDG PET using bladder radioactivity kinetics. Influence of dietary state and insulin on myocardial, skeletal muscle and brain [F]-fluorodeoxyglucose kinetics in mice. Effects of administration route, dietary condition, and blood glucose level on kinetics and uptake of 18F-FDG in mice.
